Familial Renal Insufficiency

Familial renal insufficiency.

The picture of chronic renal insufficiency in childhood is not common, and instances of more than one member of a family with this picture are comparatively rare. Mitchell (1930), in an exhaustive review of the literature of chronic interstitial nephritis in childhood, quotes 14 instances in which more than one child in the family was affected. Graham and Hutchinson (1941) have described a fami...

Familial pancreatic enzyme insufficiency.

A father and son with profound reduction of exocrine pancreatic activity and little visible pancreatic tissue on ultrasound or computed tomography are described. Both have some degree of liver disease, which is more marked in the son. The disorder, apparently familial, does not correspond to any reported previously.

[Acute renal insufficiency].

Renal insufficiency and failure.

Renal impairment is a common complication of multiple myeloma. Chronic renal failure is classified according to glomerular filtration rate as estimated by the MDRD (modification of diet in renal disease) formula, while RIFLE (risk, injury, failure, loss and end-stage renal disease) and AKIN (acute renal injury network) criteria may be used for the definition of the severity of acute renal injur...

Familial hyperlysinemia with lysine-ketoglutarate reductase insufficiency.

Fibroblasts grown in tissue culture from the skin of normal subjects have lysine-ketoglutarate reductase activity (lysine: alpha-ketoglutarate: triphosphopyridine nucleotide (TPNH) oxidoreductase (epsilon-N-[L-glutaryl-2]-L-lysine forming)). The activity of the enzyme is considerably reduced in the skin fibroblasts grown from three siblings with hyperlysinemia. The high concentrations of lysine...